A 38-year-old male present with fatigue, and weight loss. He has long history of recurrent sinusitis, epistaxis and hematuria is found to have haematuria, on urinalysis. He is c=ANCA positive. What is most likely diagnosis?

Answer: Wegner's granulomatosis
Explanation

A 38-year-old male presents with fatigue, weight loss, recurrent sinusitis, epistaxis, and hematuria on urinalysis. He is ANCA positive.

The most likely diagnosis is Wegener's granulomatosis (now known as Granulomatosis with polyangiitis).

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