Explanation

• Alpha-ketoglutarate dehydrogenase is an enzyme that catalyzes the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle (also known as the Krebs cycle or tricarboxylic acid cycle). This reaction involves both oxidation and decarboxylation, resulting in the removal of a carbon atom from the molecule and the reduction of NAD+ to NADH.
• The reaction catalyzed by alpha-ketoglutarate dehydrogenase is: alpha-ketoglutarate + NAD+ + CoA → succinyl-CoA + NADH + CO2