Which of the following best explains why hemophilia is more common in males than in females?

مندرجہ ذیل میں سے کون بہتر وضاحت کرتا ہے کہ ہیموفیلیا عورتوں کے مقابلے مردوں میں زیادہ عام کیوں ہے؟

It is caused by a dominant autosomal gene

It is a Y-linked disorder

It is inherited as an X-linked recessive trait.

It is more often acquired later in life due to liver disease

Explanation

Hemophilia is most often caused by a mutation in a gene on the X chromosome (either the F8 gene for hemophilia A or F9 for hemophilia B).

Males have one X and one Y chromosome (XY), so if their single X chromosome carries the defective gene, they will have hemophilia.

Females have two X chromosomes (XX), so a mutation would have to occur in both copies of the gene for them to show symptoms, which is much less common.

If only one X has the mutation, they are typically carriers.