The children were entrusted _______ the care of their uncle

The children were entrusted _______ the care of their uncle

Explanation

The children were entrusted with the care of their uncle

بچوں کی دیکھ بھال ان کے چچا کے سپرد تھی۔

"with" is a preposition used to indicate someone's  possessing about  something

"with" is best to keep the meaning of the original sentence