Which famous ancient trade route passed through the region of modern-day Pakistan?

Which famous ancient trade route passed through the region of modern-day Pakistan?

جدید دور کے پاکستان کے خطے سے کون سا مشہور قدیم تجارتی راستہ گزرتا تھا؟
Explanation

The Silk Road was a network of trade routes that connected Central Asia to the Arabian Sea and India.

The Karakoram Highway is a paved road that stretches 1,260 kilometers from Kashgar to Islamabad.

It passes through the areas of Taxila, Hazara, Kohistan, Besham, Chilas, Gilgit, and Hunza.